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Cleaved LC3A Antibody (ATG8a/APG8a)

CAT: 0800-F46138-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
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CAT#:0800-F46138-0.08MLSize:0.08 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. These proteins are involved in formation of autophagosomal vacuoles (autophagosomes). MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. MAP1LC3A/ATG8A is one of the light chain subunits and can associate with either MAP1A or MAP1B. The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II.
CAS Number
9007-83-4
UniProt
Q9H492
Host
Rabbit
Immunogen
A portion of amino acids 89-120 from the human protein was used as the immunogen for this ATG8a / Cleaved LC3A antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, IF, ICC, ELISA
Format
Antigen affinity purified
Buffer
In 1X PBS pH 7.4 with 0.09% sodium azide
Reconstitution
Aliquot the Cleaved LC3A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Cleaved LC3A antibody is available for research use only.

UniProtKB · Q9H492

Microtubule-associated protein 1 light chain 3 alpha

MLP3A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9H492
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MAP1LC3A
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
E1P5P4, E1P5P5, Q9BXW5
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

AutophagyUbl conjugation pathway

Cellular component

CytoplasmCytoplasmic vesicleCytoskeletonMembraneMicrotubule

PTM

LipoproteinPhosphoprotein
Product Datasheet
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