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NKX2.5 Antibody

CAT: 0800-F45607-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F45607-0.4MLSize:0.4 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This gene encodes a homeobox-containing transcription factor. This transcription factor functions in heart formation and development. Mutations in this gene cause atrial septal defect with atrioventricular conduction defect, and also tetralogy of Fallot, which are both heart malformation diseases. Mutations in this gene can also cause congenital hypothyroidism non-goitrous type 5, a non-autoimmune condition. Alternative splicing results in multiple transcript variants.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
P52952
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 2-5 from the human protein was used as the immunogen for this NKX2.5 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the NKX2.5 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This NKX2.5 antibody is available for research use only.
Storage Conditions
Aliquot the NKX2.5 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the NKX2.5 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
NKX2.5 antibody western blot analysis in mouse liver tissue lysate. Predicted molecular weight ~35kDa, routinely observed at 35~45kDa.

UniProtKB · P52952

Homeobox protein Nkx-2.5

NKX25_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P52952
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
NKX2-5
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A8K3K0, B4DNB6, E9PBU6
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Disease

Atrial septal defectCongenital hypothyroidismDisease variant

Molecular function

Developmental proteinDNA-binding

Domain

Homeobox

Cellular component

Nucleus

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