Fenspiride (hydrochloride)

Fenspiride (hydrochloride)

• CAS Number: 5053-08-7
• UNSPSC Description: Fenspiride, an orally active non-steroidal antiinflammatory agent, is an antagonist of H1-histamine receptor. Fenspiride inhibites phosphodiesterase 3 (PDE3), phosphodiesterase 4 (PDE4) and phosphodiesterase 5 (PDE5) activities with -log IC50 values of 3.44, 4.16 and approximately 3.8, respectively. Fenspiride can be used for the research of respiratory diseases[1][2][3].
• Target Antigen: Histamine Receptor; Phosphodiesterase (PDE)
• Type: Reference compound
• Related Pathways: GPCR/G Protein;Immunology/Inflammation;Metabolic Enzyme/Protease;Neuronal Signaling
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology; Endocrinology
• Assay Protocol: https://www.medchemexpress.com/Fenspiride-Hydrochloride.html
• Purity: 99.11
• Solubility: DMSO : 33.33 mg/mL (ultrasonic)|H2O : 50 mg/mL (ultrasonic)
• Smiles: O=C1OC2(CCN(CCC3=CC=CC=C3)CC2)CN1.[H]Cl
• Molecular Weight: 296.79
• References & Citations: [1]Matuszewska A, et al. Long-term administration of fenspiride has no negative impact on bone mineral density and bone turnover in young growing rats. Adv Clin Exp Med. 2019 Jun;28(6):771-776.|[2]Cortijo J, et al. Effects of fenspiride on human bronchial cyclic nucleotide phosphodiesterase isoenzymes: functional and biochemical study. Eur J Pharmacol. 1998 Jan 2;341(1):79-86.|[3]De Castro CM, et al. Fenspiride: an anti-inflammatory drug with potential benefits in the treatment of endotoxemia. Eur J Pharmacol. 1995 Dec 29;294(2-3):669-76.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: Launched