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Fenspiride

CAT: 0804-HY-A0027ASize: 1 EachDry Ice: NoHazardous: No
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Description
Fenspiride, an orally active non-steroidal antiinflammatory agent, is an antagonist of H1-histamine receptor. Fenspiride inhibites phosphodiesterase 3 (PDE3), phosphodiesterase 4 (PDE4) and phosphodiesterase 5 (PDE5) activities with -log IC50 values of 3.44, 4.16 and approximately 3.8, respectively. Fenspiride can be used for the research of respiratory diseases[1][2][3].
CAS Number
5053-06-5
UNSPSC
12352005
Hazard Statement
H302-H361-H412
Target
Histamine Receptor; Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/fenspiride.html
Solubility
10 mM in DMSO
Smiles
O=C1OC2(CCN(CCC3=CC=CC=C3)CC2)CN1
Molecular Formula
C15H20N2O2
Molecular Weight
260.33
Precautions
P264-P270-P273-P280-P330-P405-P501
References & Citations
[1]Matuszewska A, et al. Long-term administration of fenspiride has no negative impact on bone mineral density and bone turnover in young growing rats. Adv Clin Exp Med. 2019 Jun;28 (6) :771-776.|[2]Cortijo J, et al. Effects of fenspiride on human bronchial cyclic nucleotide phosphodiesterase isoenzymes: functional and biochemical study. Eur J Pharmacol. 1998 Jan 2;341 (1) :79-86.|[3]De Castro CM, et al. Fenspiride: an anti-inflammatory drug with potential benefits in the treatment of endotoxemia. Eur J Pharmacol. 1995 Dec 29;294 (2-3) :669-76.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
H1 Receptor; PDE3; PDE4; PDE5

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