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ISL1 Antibody / Islet 1

CAT: 0800-F44709-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
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CAT#:0800-F44709-0.08MLSize:0.08 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ISL1 is a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
P61371
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 156-185 from the human protein was used as the immunogen for this ISL1 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the ISL1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This ISL1 antibody is available for research use only.
Storage Conditions
Aliquot the ISL1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the ISL1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Chicken, Rat, Zebrafish
Image Legend
ISL1 antibody western blot analysis in MDA-MB231 lysate. Predicted molecular weight ~39 kDa.

UniProtKB · P61371

Insulin gene enhancer protein ISL-1

ISL1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P61371
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ISL1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Islet-1
EC number
—
Processing
—
Secondary accessions
P20663, P47894
Protein keywords

Molecular function

ActivatorDevelopmental proteinDNA-binding

Biological process

DifferentiationTranscriptionTranscription regulation

Domain

HomeoboxLIM domainRepeat

Ligand

Metal-bindingZinc

Cellular component

Nucleus

PTM

PhosphoproteinUbl conjugation

Technical term

Proteomics identificationReference proteome

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