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Aurka Antibody

CAT: 0800-F44002-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
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CAT#:0800-F44002-0.08MLSize:0.08 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Contributes to the regulation of cell cycle progression. Required for normal mitosis. Associates with the centrosome and the spindle microtubules during mitosis and functions in centrosome maturation, spindle assembly, maintenance of spindle bipolarity, centrosome separation and mitotic checkpoint control. Phosphorylates numerous target proteins, including ARHGEF2, BRCA1, KIF2A, NDEL1, PARD3, PLK1 and BORA. Regulates KIF2A tubulin depolymerase activity (By similarity) . Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
P97477
Host
Rabbit
Reactivity
Mouse
Immunogen
A portion of amino acids 93-120 from the mouse protein was used as the immunogen for this Aurka antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Aurka antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Aurka antibody is available for research use only.
Storage Conditions
Aliquot the Aurka antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the Aurka antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Aurka antibody western blot analysis in mouse NIH3T3 lysate. Predicted molecular weight ~45 kDa.

UniProtKB · P97477

Aurora kinase A

AURKA_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
P97477
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Aurka
Protein existence
1: Evidence at protein level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
—
EC number
2.7.11.1
Processing
—
Secondary accessions
O35624, Q8C3H8, Q91YU4
Protein keywords

Technical term

3D-structureReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Biological process

Cell cycleCell divisionCilium biogenesis/degradationMitosis

Cellular component

Cell membraneCell projectionCiliumCytoplasmCytoskeletonMembraneMicrotubule

PTM

Isopeptide bondPhosphoproteinUbl conjugation

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

Disease

Proto-oncogene

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