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FAP Antibody

CAT: 0800-F42270-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
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CAT#:0800-F42270-0.08MLSize:0.08 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Fibroblast activation protein is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
Q12884
Host
Rabbit
Reactivity
Human
Immunogen
This FAP antibody was produced from rabbits immunized with the protein of human FAP.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Strore at 4oC for up to one month. For long term, aliquot the FAP antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This FAP antibody is available for research use only.
Storage Conditions
Strore at 4°C for up to one month. For long term, aliquot the FAP antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the FAP antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
FAP antibody western blot analysis in NCI-H292 lysate. Predicted molecular weight 88~95 kDa (monomer) and 170 kDa (dimer)

UniProtKB · Q12884

Prolyl endopeptidase FAP

SEPR_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q12884
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FAP
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.4.21.26
Processing
—
Secondary accessions
O00199, Q53TP5, Q86Z29, Q99998, Q9UID4
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

AngiogenesisApoptosisCell adhesion

Cellular component

Cell junctionCell membraneCell projectionCytoplasmMembraneSecreted

PTM

Cleavage on pair of basic residuesDisulfide bondGlycoprotein

Molecular function

HydrolaseProteaseSerine protease

Domain

Signal-anchorTransmembraneTransmembrane helix
Product Datasheet
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