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H-RAS Antibody

CAT: 0800-F41616-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
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CAT#:0800-F41616-0.08MLSize:0.08 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, Immunofluorescence: 1:10-1:50
UniProt
P01112
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 146-176 from the human protein was used as the immunogen for this H-RAS antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IF, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the H-RAS antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This H-RAS antibody is available for research use only.
Storage Conditions
Aliquot the H-RAS antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the H-RAS antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Rat, Chicken
Image Legend
H-RAS antibody western blot analysis in mouse cerebellum tissue lysate. Predicted molecular weight ~ 21 kDa.

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