Integrin beta 2 Antibody

• Description:

  The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1) . Two transcript variants encoding the same protein have been identified for this gene.

• Specifications:

  IHC (Paraffin) : 1:25, Western blot: 1:100-1:1000

• UniProt:

  P05107

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Purified His-tagged protein fragment was used to produced this monoclonal Integrin beta 2/CD18 antibody.

• Clonality:

  Monoclonal

• Isotype:

  IgG1

• Clone:

  534CT6.2.1

• Applications:

  IHC, WB, ELISA

• Purity:

  Purified

• Format:

  Purified

• Buffer:

  In 1X PBS, pH 7.4, with 0.09% sodium azide

• Reconstitution:

  Aliquot the Integrin beta 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

• Limitations:

  This Integrin beta 2 antibody is available for research use only.

• Storage Conditions:

  Aliquot the Integrin beta 2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

• Formulation:

  In 1X PBS, pH 7.4, with 0.09% sodium azide

• Applications Notes:

  Titration of the Integrin beta 2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

• CAS Number:

  9007-83-4

• Image Legend:

  Immunohistochemical analysis of paraffin-embedded human tonsil using Integrin beta 2 antibody at 1:25 dilution.