LIN28A Antibody

CAT: 0800-F40207-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
CAT#:0800-F40207-0.4MLSize:0.4 mL
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LIN28A is a translational enhancer that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (By similarity) . Suppressor of microRNA (miRNA) biogenesis, including that of let-7, miR107, miR-143 and miR-200c. Specifically binds miRNA precursors (pre-miRNAs), recognizing an 5'-GGAG-3' motif found in pre-miRNA terminal loop, and recruits ZCCHC11/TUT4 uridylyltransferase. This results in the terminal uridylation of target pre-miRNAs. Uridylated pre-miRNAs fail to be processed by Dicer and undergo degradation.[UniProt]
CAS Number
9007-83-4
Specifications
Western blot: 1:200-1:2000, IHC (Paraffin) : 1:50-1:200, Immunofluorescence: 1:10-1:50
UniProt
Q9H9Z2
Host
Mouse
Reactivity
Human
Immunogen
LIN28A recombinant protein was used to produce this monoclonal antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
55CT58.12.1
Applications
WB, IHC, IF, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the LIN28A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This LIN28A antibody is available for research use only.
Storage Conditions
Aliquot the LIN28A antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the LIN28A antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot analysis of recombinant protein with LIN28A antibody
Product Datasheet
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