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CCND1 Antibody

CAT: 0800-F40063-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F40063-0.4MLSize:0.4 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CCND1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of the gene encoding this protein, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
Q6FI00
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 147-175 from the human protein was used as the immunogen for this CCND1 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the CCND1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This CCND1 antibody is available for research use only.
Storage Conditions
Aliquot the CCND1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the CCND1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot analysis of CCND1 antibody ans 293 cell lysate (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CCND1 gene (2) . Predicted molecular weight: 32-36 kDa.

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