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P4HA3 rabbit pAb

CAT: 0855-ES14318-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES14318-01Size:50 µL
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Background
This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Description
This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014],
UniProt
Q7Z4N8
Swiss Prot
Q7Z4N8
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human P4HA3 AA range: 211-261
Target
P4HA3
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Endoplasmic reticulum lumen .
Gene ID (Human)
283208

UniProtKB · Q7Z4N8

Prolyl 4-hydroxylase subunit alpha-3

P4HA3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q7Z4N8
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
P4HA3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
4-PH alpha-3
EC number
1.14.11.2
Processing
Precursor
Secondary accessions
A0AV13, B4DUD3, Q5EBL3, Q5JPA9
Protein keywords

Coding sequence diversity

Alternative splicing

Domain

Coiled coilSignalTPR repeat

Molecular function

DioxygenaseOxidoreductase

Cellular component

Endoplasmic reticulum

PTM

Glycoprotein

Ligand

IronMetal-bindingVitamin C

Technical term

Proteomics identificationReference proteome

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