BMPR2-IN-1 (TFA)

BMPR2-IN-1 (TFA)

• UNSPSC Description: BMPR2-IN-1 (Compound 8a) is a BMPR2 inhibitor with an IC50 of 506 nM and a KD of 83.5 nM. BMPR2-IN-1 can be used for research of pulmonary arterial hypertension, Alzheimer’s disease and cancer[1].
• Target Antigen: TGF-β Receptor
• Type: Reference compound
• Related Pathways: TGF-beta/Smad
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/bmpr2-in-1-tfa.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C1NCCC2=CC=C(NC3=NC(NC4=NNC1=C4)=CC=N3)C=C2.OC(C(F)(F)F)=O
• Molecular Weight: 435.36
• References & Citations: [1]Amrhein JA, et al. Design and Synthesis of Pyrazole-Based Macrocyclic Kinase Inhibitors Targeting BMPR2. ACS Med Chem Lett. 2023 May 30;14(6):833-840.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported