Strictosamide

CAT: 0804-HY-N1198-03Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-N1198-03Size:10 mg

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Description

Strictosamide is a compound that can be isolated from Nauclea officinalis. Strictosamide has various activities such as anti-inflammatory, analgesic, anti-Plasmodium, antifungal, and promoting wound healing[1][2][3][4][5].

CAS Number

23141-25-5

UNSPSC

12352005

Target

Akt; Fungal; Interleukin Related; JNK; Na+/K+ ATPase; NF-κB; NO Synthase; p38 MAPK; Parasite; PERK; PI3K

Type

Natural Products

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Immunology/Inflammation; MAPK/ERK Pathway; Membrane Transporter/Ion Channel; NF-κB; PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/strictosamide.html

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1N2CCC3=C(NC4=C3C=CC=C4)[C@]2([H])C[C@]5([H])C1=CO[C@@H](O[C@H]6[C@@H]([C@H]([C@@H]([C@@H](CO)O6)O)O)O)[C@@H]5C=C

Molecular Formula

C26H30N2O8

Molecular Weight

498.53

References & Citations

[1]Na Li, et al. In vivo anti-inflammatory and analgesic activities of strictosamide from Nauclea officinalis. Pharm Biol. 2014 Nov;52 (11) :1445-50.|[2]Candeias MF, et al. Effects of strictosamide on mouse brain and kidney Na+, K+-ATPase and Mg2+-ATPase activities. J Ethnopharmacol. 2009 Jan 12;121 (1) :117-22.|[3]Li D, et al. Anti-inflammatory effect of the six compounds isolated from Nauclea officinalis Pierrc ex Pitard, and molecular mechanism of strictosamide via suppressing the NF-κB and MAPK signaling pathway in LPS-induced RAW 264.7 macrophages. J Ethnopharmacol. 2017 Jan 20;196:66-74.|[4]Ming GX, et al. Strictosamide promotes wound healing through activation of the PI3K/AKT pathway. Heliyon. 2024 Apr 23;10 (9) :e30169.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Chemical Information

Strictosamide

Strictosamide is a member of beta-carbolines.

CAS Number	23141-25-5
PubChem CID	10345799
IUPAC Name	(1S,18S,19R,20S)-19-ethenyl-18-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-2(10),4,6,8,15-pentaen-14-one
Molecular Formula	C26H30N2O8
Molecular Weight	498.5
XLogP	0.4
Topological Polar Surface Area	145
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	4
Heavy Atom Count	36
Formal Charge	0
Complexity	899

SMILES

C=C[C@@H]1[C@@H]2C[C@H]3C4=C(CCN3C(=O)C2=CO[C@H]1O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O)C6=CC=CC=C6N4

InChI

InChI=1S/C26H30N2O8/c1-2-12-15-9-18-20-14(13-5-3-4-6-17(13)27-20)7-8-28(18)24(33)16(15)11-34-25(12)36-26-23(32)22(31)21(30)19(10-29)35-26/h2-6,11-12,15,18-19,21-23,25-27,29-32H,1,7-10H2/t12-,15+,18+,19-,21-,22+,23-,25+,26+/m1/s1

InChIKey

LBRPLJCNRZUXLS-IUNANRIWSA-N

Chemical Structure

2D Structure

CAS: 23141-25-5

CID: 10345799

Formula: C26H30N2O8

MW: 498.5

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	498.5
XLogP3	0.4
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	4
Exact Mass	498.20021592
Monoisotopic Mass	498.20021592
Topological Polar Surface Area	145 Å²
Heavy Atom Count	36
Formal Charge	0
Complexity	899
Isotope Atom Count	0
Defined Atom Stereocenter Count	9
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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TBW01739	Strictosamide

Strictosamide

Chemical Information

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