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Strictosamide

CAT: 0804-HY-N1198-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N1198-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Strictosamide is a compound that can be isolated from Nauclea officinalis. Strictosamide has various activities such as anti-inflammatory, analgesic, anti-Plasmodium, antifungal, and promoting wound healing[1][2][3][4][5].
CAS Number
23141-25-5
UNSPSC
12352005
Target
Akt; Fungal; Interleukin Related; JNK; Na+/K+ ATPase; NF-κB; NO Synthase; p38 MAPK; Parasite; PERK; PI3K
Type
Natural Products
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Immunology/Inflammation; MAPK/ERK Pathway; Membrane Transporter/Ion Channel; NF-κB; PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/strictosamide.html
Purity
99.94
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1N2CCC3=C(NC4=C3C=CC=C4)[C@]2([H])C[C@]5([H])C1=CO[C@@H](O[C@H]6[C@@H]([C@H]([C@@H]([C@@H](CO)O6)O)O)O)[C@@H]5C=C
Molecular Formula
C26H30N2O8
Molecular Weight
498.53
References & Citations
[1]Na Li, et al. In vivo anti-inflammatory and analgesic activities of strictosamide from Nauclea officinalis. Pharm Biol. 2014 Nov;52 (11) :1445-50.|[2]Candeias MF, et al. Effects of strictosamide on mouse brain and kidney Na+, K+-ATPase and Mg2+-ATPase activities. J Ethnopharmacol. 2009 Jan 12;121 (1) :117-22.|[3]Li D, et al. Anti-inflammatory effect of the six compounds isolated from Nauclea officinalis Pierrc ex Pitard, and molecular mechanism of strictosamide via suppressing the NF-κB and MAPK signaling pathway in LPS-induced RAW 264.7 macrophages. J Ethnopharmacol. 2017 Jan 20;196:66-74.|[4]Ming GX, et al. Strictosamide promotes wound healing through activation of the PI3K/AKT pathway. Heliyon. 2024 Apr 23;10 (9) :e30169.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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CatalogName
TBW01739Strictosamide

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