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Dimethoate-d6

CAT: 0804-HY-B1946S-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1946S-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dimethoate-d6 is the deuterium labeled Dimethoate. Dimethoate is an organophosphate insecticide and acaricide. Dimethoate is an orally active acetylcholinesterase inhibitor. Dimethoate induces reactive oxygen species (ROS) . Dimethoate induces DNA damage and cell apoptosis in vivo. Dimethoate affect immune system in mice[1][2][3][4][5].
CAS Number
1219794-81-6
UNSPSC
12352211
Hazard Statement
H301+H311
Target
Apoptosis; Cholinesterase (ChE) ; Insecticide; Isotope-Labeled Compounds; Reactive Oxygen Species (ROS)
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; Others
Field of Research
Inflammation/Immunology
Purity
99.86
Solubility
10 mM in DMSO
Smiles
S=P(OC([2H])([2H])[2H])(SCC(NC)=O)OC([2H])([2H])[2H]
Molecular Formula
C5H6D6NO3PS2
Molecular Weight
235.29
Precautions
H301+H311
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]CASIDA JE, et al. Toxic hazard from formulating the insecticide dimethoate in methyl 'Cellosolve'. Nature. 1961;189:507-508.|[3]Martínez-Morcillo S, et al. The organophosphorus pesticide dimethoate decreases cell viability and induces changes in different biochemical parameters of rat pancreatic stellate cells. Toxicol In Vitro. 2019 Feb;54:89-97.|[4]Nazam N, et al. Dimethoate Induces DNA Damage and Mitochondrial Dysfunction Triggering Apoptosis in Rat Bone-Marrow and Peripheral Blood Cells. Toxics. 2020 Oct 1;8 (4) :80.|[5]Aly NM, et al. Effect of dimethoate on the immune system of female mice. J Environ Sci Health B. 2000 Jan;35 (1) :77-86.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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