Dimethoate

• Description:

  Dimethoate is an organophosphate insecticide and acaricide. Dimethoate is an orally active acetylcholinesterase inhibitor. Dimethoate induces reactive oxygen species (ROS) . Dimethoate induces DNA damage and cell apoptosis in vivo. Dimethoate affect immune system in mice[1][2][3].

• UNSPSC:

  12352211

• Hazard Statement:

  H301+H311

• Target:

  Apoptosis; Cholinesterase (ChE) ; Insecticide; Reactive Oxygen Species (ROS)

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; Others

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/dimethoate.html

• Purity:

  99.91

• Solubility:

  H2O : 10 mg/mL (ultrasonic)

• Smiles:

  S=P(OC)(SCC(NC)=O)OC

• Molecular Formula:

  C5H12NO3PS2

• Molecular Weight:

  229.26

• Precautions:

  H301+H311

• References & Citations:

  [1]Martínez-Morcillo S, et al. The organophosphorus pesticide dimethoate decreases cell viability and induces changes in different biochemical parameters of rat pancreatic stellate cells. Toxicol In Vitro. 2019 Feb;54:89-97.|[2]Nazam N, et al. Dimethoate Induces DNA Damage and Mitochondrial Dysfunction Triggering Apoptosis in Rat Bone-Marrow and Peripheral Blood Cells. Toxics. 2020 Oct 1;8 (4) :80.|[3]Aly NM, et al. Effect of dimethoate on the immune system of female mice. J Environ Sci Health B. 2000 Jan;35 (1) :77-86.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, stored under nitrogen)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 4

• CAS Number:

  [60-51-5]