Ribociclib-d6 (hydrochloride)

Ribociclib-d6 (hydrochloride)

• UNSPSC Description: Ribociclib-d6 (hydrochloride) is a deuterium labeled Ribociclib. Ribociclib is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex[1].
• Target Antigen: CDK
• Type: Isotope-Labeled Compounds
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C(C1=CC2=CN=C(NC3=NC=C(N4CCNCC4)C=C3)N=C2N1C5CCCC5)N(C([2H])([2H])[2H])C([2H])([2H])[2H].Cl
• Molecular Weight: 477.04
• References & Citations: [1]VanArsdale T, et al. Molecular Pathways: Targeting the Cyclin D-CDK4/6 Axis for Cancer Treatment. Clin Cancer Res. 2015 Jul 1;21(13):2905-10.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported