Benzocaine (hydrochloride)

Benzocaine (hydrochloride)

• CAS Number: 23239-88-5
• UNSPSC Description: Benzocaine (hydrochloride) is an orally active local agent that can suppress or relieve pain, that acts on voltage-gated Na+ channels at a common receptor, with an IC50 value of 0.8 mM at +30 mV. Additionally, Benzocaine (hydrochloride) non-competitively inhibits Ca-ATPase binding with Ca2+, with an IC50 of 47.1 mM. Benzocaine (hydrochloride) can be used in research within the field of neuromuscular regulation[1][2][3].
• Target Antigen: Bacterial; Sodium Channel
• Type: Reference compound
• Related Pathways: Anti-infection;Membrane Transporter/Ion Channel
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/benzocaine-hydrochloride.html
• Purity: 99.31
• Smiles: O=C(OCC)C1=CC=C(N)C=C1.[H]Cl
• Molecular Weight: 201.653
• References & Citations: [1]Wang GK, et al. A common local anesthetic receptor for benzocaine and etidocaine in voltage-gated mu1 Na+ channels. Pflugers Arch. 1998 Jan;435(2):293-302.|[2]Davis JA, et al. Benzocaine-induced methemoglobinemia attributed to topical application of the anesthetic in several laboratory animal species. Am J Vet Res. 1993 Aug;54(8):1322-6.|[3]Di Croce D, et al. Drug action of benzocaine on the sarcoplasmic reticulum Ca-ATPase from fast-twitch skeletal muscle. Naunyn Schmiedebergs Arch Pharmacol. 2015 Nov;388(11):1163-70.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture and light)
• Clinical Information: Launched