Benzocaine

• Description :

  Benzocaine shares a common receptor with all othe rLAs in the voltage-gated Na+ channel, with an IC50 of 0.8 mM tested with a potential of +30 mV.

• UNSPSC :

  12352005

• Hazard Statement :

  H317, H402

• Target :

  Bacterial; Sodium Channel

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Membrane Transporter/Ion Channel

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/Benzocaine.html

• Purity :

  99.98

• Solubility :

  DMSO : ≥ 100 mg/mL|H2O : 2 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  O=C(OCC)C1=CC=C(N)C=C1

• Molecular Formula :

  C9H11NO2

• Molecular Weight :

  165.19

• Precautions :

  H317, H402

• References & Citations :

  [1]Wang GK et al. A common local anesthetic receptor for benzocaine and etidocaine in voltage-gated mu1 Na+ channels. Pflugers Arch. 1998 Jan;435 (2) :293-302.|[2]Di Croce D et al. Drug action of benzocaine on the sarcoplasmic reticulum Ca-ATPase from fast-twitch skeletal muscle. Naunyn Schmiedebergs Arch Pharmacol. 2015 Nov;388 (11) :1163-70.|[3]Davis JA, et al. Benzocaine-induced methemoglobinemia attributed to topical application of the anesthetic in several laboratory animal species. Am J Vet Res. 1993 Aug;54 (8) :1322-6.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  RT, protect from light

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• CAS Number :

  [94-09-7]