4″-C18 EGCG

• Description :

  4″-C18 EGCG is a potent inhibitor of α-amylase and α-glucosidase with IC50 values of 3.74 and 0.81 μM, respectively. 4″-C18 EGCG inhibits carbohydrate hydrolases, reduces oxidative stress and inflammation, and exhibits antidiabetic activity. 4″-C18 EGCG also downregulates proinflammatory cytokines and is cytotoxic to primary human peripheral blood mononuclear cells (PBMCs), non-cancer cell lines 3T3-L1, and HEK 293 at 50 μM[1].

• UNSPSC :

  12352005

• Target :

  Amylases; Glycosidase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/4-c18-egcg.html

• Smiles :

  OC(C(O)=C1)=C(O)C=C1[C@@H](O2)[C@H](OC(C3=CC(O)=C(OCCCCCCCCCCCCCCCCCC)C(O)=C3)=O)CC4=C2C=C(O)C=C4O

• Molecular Formula :

  C40H54O11

• Molecular Weight :

  710.85

• References & Citations :

  [1]Kothari M, et al. Lipophilic derivatives of EGCG as potent α-amylase and α-glucosidase inhibitors ameliorating oxidative stress and inflammation[J]. Bioorganic Chemistry, 2024: 107786.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported