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Spinosad

CAT: 0804-HY-138800-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-138800-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Spinosad, a mixture of spinosyns A and D known as fermentation products of a soil actinomycete (Saccharopolyspora spinosa), is a biological neurotoxic insecticide with a broader action spectrum. Spinosad targets the nicotinic acetylcholine receptor (nAChRs) of the insect nervous system. Spinosad has an excellent environmental and mammalian toxicological profile. Larvicidal activity[1][2][3].
CAS Number
168316-95-8
UNSPSC
12352005
Hazard Statement
H410
Target
NAChR
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/spinosad.html
Purity
97.90
Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC1=C[C@]2([H])[C@](C=C3[C@@]2([H])CC(O[C@H](CCC[C@@H]([C@H](C3=O)C)O[C@@H]4O[C@@H]([C@H](CC4)N(C)C)C)CC)=O)([H])[C@@]5([H])[C@@]1([H])C[C@H](C5)O[C@H]6[C@@H]([C@@H]([C@H]([C@@H](O6)C)OC)OC)OC.O=C([C@@H]([C@H](CCC[C@@H](O7)CC)O[C@@H]8O[C@@H]([C@H](CC8)N(C)C)C)C)C9=C[C@@]([C@](C=C[C@]%10([H])C%11)([H])[C@]9([H])CC7=O)([H])[C@]%10([H])C[C@@H]%11O[C@H]%12[C@@H]([C@@H]([C@H]([C@@H](O%12)C)OC)OC)OC
Molecular Formula
C83H132N2O20
Molecular Weight
1477.94
Precautions
H410
References & Citations
[1]Duchet C, et al. Effects of Bacillus thuringiensis israelensis and spinosad on adult emergence of the non-biting midges Polypedilum nubifer (Skuse) and Tanytarsus curticornis Kieffer (Diptera: Chironomidae) in coastal wetlands. Ecotoxicol Environ Saf. 2015;115:272-278.|[2]Wang J, et al. A three amino acid deletion in the transmembrane domain of the nicotinic acetylcholine receptor α6 subunit confers high-level resistance to spinosad in Plutella xylostella. Insect Biochem Mol Biol. 2016;71:29-36.|[3]Huang J, et al. High Level of Spinosad Production in the Heterologous Host Saccharopolyspora erythraea. Appl Environ Microbiol. 2016;82 (18) :5603-5611. Published 2016 Aug 30.|[4]McCormack PL. Spinosad: in pediculosis capitis. Am J Clin Dermatol. 2011;12 (5) :349-353.|[5]Piner P, et al. Organic insecticide spinosad causes in vivo oxidative effects in the brain of Oreochromis niloticus. Environ Toxicol. 2014;29 (3) :253-260.|[6]Santos VSV, et al. Properties, toxicity and current applications of the biolarvicide spinosad. J Toxicol Environ Health B Crit Rev. 2020;23 (1) :13-26.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Launched

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