PI3K-IN-18
CAT:
804-HY-109633
Size:
5 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
PI3K-IN-18
- CAS Number: 371943-05-4
- UNSPSC Description: PI3K-IN-18 (Compound 1) is a PI3K inhibitor, and can also effectively inhibit the homologous enzymemTOR. The IC50 values of PI3K-IN-18 for mTOR and PI3K-α were 49 nM and 41 nM, respectively[1].
- Target Antigen: mTOR; PI3K
- Type: Reference compound
- Related Pathways: PI3K/Akt/mTOR
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/pi3k-in-18.html
- Purity: 99.0
- Solubility: DMSO : 25 mg/mL (ultrasonic;warming)
- Smiles: OC1=CC(C2=NC3=C(C(N4CCOCC4)=N2)SC=C3)=CC=C1
- Molecular Weight: 313.37
- References & Citations: [1]Verheijen, Jeroen C et al. “Discovery of 2-arylthieno[3,2-d]pyrimidines containing 8-oxa-3-azabi-cyclo[3.2.1]octane in the 4-position as potent inhibitors of mTOR with selectivity over PI3K.” Bioorganic & medicinal chemistry letters vol. 20,1 (2010): 375-9.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years (Powder)
- Clinical Information: No Development Reported