TCO-PEG8-NHS ester

TCO-PEG8-NHS ester

• CAS Number: 2353409-95-5
• UNSPSC Description: TCO-PEG8-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. TCO-PEG8-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
• Target Antigen: PROTAC Linkers
• Type: Reference compound
• Related Pathways: PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/tco-peg8-nhs-ester.html
• Solubility: H2O : ≥ 100 mg/mL
• Smiles: O=C(OC1CC/C=C\CCC1)NCCOCCOCCOCCOCCOCCOCCOCCOCCC(ON2C(CCC2=O)=O)=O
• Molecular Weight: 690.78
• References & Citations: [1]Wang Y, et al. Degradation of proteins by PROTACs and other strategies. Acta Pharm Sin B. 2020 Feb;10(2):207-238.
• Shipping Conditions: Blue Ice
• Clinical Information: No Development Reported