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Prostaglandin E1

CAT: 0804-HY-B0131-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0131-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases[1][2][3].
CAS Number
745-65-3
Product Name Alternative
Alprostadil; PGE1
UNSPSC
12352211
Hazard Statement
H301
Target
Endogenous Metabolite; Prostaglandin Receptor
Type
Natural Products
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology; Cardiovascular Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/prostaglandin-e1.html
Purity
99.76
Solubility
DMSO : 100 mg/mL (ultrasonic) |Ethanol : 100 mg/mL (ultrasonic)
Smiles
CCCCC[C@H](O)/C=C/[C@@H]1[C@H](C(C[C@H]1O)=O)CCCCCCC(O)=O
Molecular Formula
C20H34O5
Molecular Weight
354.48
Precautions
H301
References & Citations
[1]Kiriyama M, et, al. Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122 (2) :217-24.|[2]Cattaneo MG, et, al. Alprostadil suppresses angiogenesis in vitro and in vivo in the murine Matrigel plug assay. Br J Pharmacol. 2003 Jan;138 (2) :377-85.|[3]Hauck EW, et, al. Prostaglandin E1 long-term self-injection programme for treatment of erectile dysfunction--a follow-up of at least 5 years. Andrologia. 1999;31 Suppl 1:99-103.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
EP; Human Endogenous Metabolite

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