Jacaric acid

• UNSPSC Description:

  Jacaric acid is a conjugated linolenic acid, which inhibits viability in cells PC-3 (IC50 is 11.8 μM), LNCaP (IC50 is 2.2 μM) and DLD-1, induces apoptosis and necrosis[1]. Jacaric acid exhibits anticaner activity against prostate cancer and adenocarcinoma[2]. Jacaric acid exhibits immunomodulating activity in murine peritoneal macrophages as an immunopotentiator[3]. Jacaric acid is orally active.

• Target Antigen:

  Apoptosis

• Type:

  Natural Products

• Related Pathways:

  Apoptosis

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/jacaric-acid.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CCCCC/C=C\C=C\C=C/CCCCCCC(O)=O

• Molecular Weight:

  278.43

• References & Citations:

  [1]Gasmi J, et al., Jacaric acid and its octadecatrienoic acid geoisomers induce apoptosis selectively in cancerous human prostate cells: a mechanistic and 3-D structure-activity study. Phytomedicine. 2013 Jun 15;20(8-9):734-42..|[2]Shinohara N, et al., Jacaric acid, a linolenic acid isomer with a conjugated triene system, has a strong antitumor effect in vitro and in vivo. Biochim Biophys Acta. 2012 Jul;1821(7):980-8.|[3]Liu WN, et al., The Immunomodulatory Activity of Jacaric Acid, a Conjugated Linolenic Acid Isomer, on Murine Peritoneal Macrophages. PLoS One. 2015 Dec 2;10(12):e0143684.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  28872-28-8