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LSD1, Human Recombinant

CAT: 0026-P1659-50Size: 50 µgDry Ice: NoHazardous: No
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CAT#:0026-P1659-50Size:50 µg
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Description
The mono, di- and trimethylation of particular lysine residues in histone tails (e.g. histone H3 lysine-4 (H3K4), H3K9, H3K27, H3K36, H4K20) are implicated in the transmission of heritable epigenetic information and the control of chromatin structure and DNA transcription. LSD1 catalyzes the oxidative demethylation of mono- and dimethylated H3K4, producing hydrogen peroxide and formaldehyde in the process. H3K4 methylation is considered a transcription activating chromatin mark. In vivo LSD1 is frequently found in association with the transcriptional corepressor protein CoREST and HDACs 1 or 2. Its expression is elevated in a number of cancers, which makes it a promising target for drug development. LSD1 is inhibited by a number of established monoamine oxidase inhibitor drugs.
CAS Number
9000-83-3
Shipping Conditions
Gel Pack
Storage Conditions
-80°C
Shelf Life
12 months

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