LSD1, Human Recombinant

• Description:

  The mono, di- and trimethylation of particular lysine residues in histone tails (e.g. histone H3 lysine-4 (H3K4), H3K9, H3K27, H3K36, H4K20) are implicated in the transmission of heritable epigenetic information and the control of chromatin structure and DNA transcription. LSD1 catalyzes the oxidative demethylation of mono- and dimethylated H3K4, producing hydrogen peroxide and formaldehyde in the process. H3K4 methylation is considered a transcription activating chromatin mark. In vivo LSD1 is frequently found in association with the transcriptional corepressor protein CoREST and HDACs 1 or 2. Its expression is elevated in a number of cancers, which makes it a promising target for drug development. LSD1 is inhibited by a number of established monoamine oxidase inhibitor drugs.

• CAS Number:

  9000-83-3

• Shipping Conditions:

  Gel Pack

• Storage Conditions:

  -80°C

• Shelf Life:

  12 months