CHM-1

CAT: 0804-HY-103257-02Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-103257-02Size:5 mg

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Description

CHM-1, a microtubule-destabilizing agent, inhibits tubulin polymerization. CHM-1 is a potent and selective antimitotic antitumor activity against human hepatocellular carcinoma. CHM-1 induces growth inhibition and apoptosis via G2-M phase arrest in human hepatocellular carcinoma cells by activation of Cdc2 kinase activity[1][2][3].

CAS Number

154554-41-3

Product Name Alternative

NSC656158

UNSPSC

12352005

Target

Microtubule/Tubulin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/chm-1.html

Purity

99.57

Solubility

DMSO : 5 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C=C(C2=CC=CC=C2F)NC3=C1C=C4C(OCO4)=C3

Molecular Formula

C16H10FNO3

Molecular Weight

283.25

References & Citations

[1]Wang SW, et al. CHM-1, a novel synthetic quinolone with potent and selective antimitotic antitumor activity against human hepatocellular carcinoma in vitro and in vivo. Mol Cancer Ther. 2008 Feb;7 (2) :350-60.|[2]Liu CW, et al. CHM-1, a novel microtubule-destabilizing agent exhibits antitumor activity via inducing the expression of SIRT2 in human breast cancer cells. Chem Biol Interact. 2018 Jun 1;289:98-108.|[3]Tsai AC, et al. CHM-1, a new vascular targeting agent, induces apoptosis of human umbilical vein endothelial cells via p53-mediated death receptor 5 up-regulation. J Biol Chem. 2010 Feb 19;285 (8) :5497-506.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Chemical Information

6-(2-Fluorophenyl)-1,3-dioxolo(4,5-g)quinolin-8(5H)-one

CAS Number	154554-41-3
PubChem CID	375860
IUPAC Name	6-(2-fluorophenyl)-5H-[1,3]dioxolo[4,5-g]quinolin-8-one
Molecular Formula	C16H10FNO3
Molecular Weight	283.25
XLogP	3.1
Topological Polar Surface Area	47.6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	1
Heavy Atom Count	21
Formal Charge	0
Complexity	466

SMILES

C1OC2=C(O1)C=C3C(=C2)C(=O)C=C(N3)C4=CC=CC=C4F

InChI

InChI=1S/C16H10FNO3/c17-11-4-2-1-3-9(11)12-6-14(19)10-5-15-16(21-8-20-15)7-13(10)18-12/h1-7H,8H2,(H,18,19)

InChIKey

ZMYDAPJHGNEFGQ-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 154554-41-3

CID: 375860

Formula: C16H10FNO3

MW: 283.25

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	283.25
XLogP3	3.1
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	1
Exact Mass	283.06447134
Monoisotopic Mass	283.06447134
Topological Polar Surface Area	47.6 Å²
Heavy Atom Count	21
Formal Charge	0
Complexity	466
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Alternative Products

Catalog	Name
444460-01	CHM-1
A4450-1	CHM 1
A15332-200	CHM 1 200mg
A15332-50	CHM 1 50mg
A15332-5	CHM 1 5mg
A15332-1	CHM 1 1mg
A15332-10	CHM 1 10mg
BZ0440-1	PcDNA3.1-CHM
A15332-100	CHM 1 100mg
A15332-25	CHM 1 25mg

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