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1-Hydroxypyrene

CAT: 0804-HY-W014075-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W014075-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
1-Hydroxypyrene, a biomarker of exposure to polycyclic aromatic hydrocarbons (PAHs), is analyzed in urine samples. 1-Hydroxypyrene is the major biomarker of exposure to pyrenes. 1-Hydroxypyrene is the orally active agonist for aryl hydrocarbon receptor (AhR) and can lead to renal fibrosis[1][2].
CAS Number
5315-79-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Aryl Hydrocarbon Receptor; Collagen; Cytochrome P450
Type
Natural Products
Related Pathways
Cytoskeleton; Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/1-hydroxypyrene.html
Purity
99.84
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OC1=C(C2=C34)C=CC4=CC=CC3=CC=C2C=C1
Molecular Formula
C16H10O
Molecular Weight
218.25
Precautions
H302, H315, H319, H335
References & Citations
[1]Fernando Freitas, et al. Urinary 1-hydroxypyrene Is Associated With Oxidative Stress and Inflammatory Biomarkers in Acute Myocardial Infarction. Int J Environ Res Public Health|[2]Miao H, et al., 1-Hydroxypyrene mediates renal fibrosis through aryl hydrocarbon receptor signalling pathway. Br J Pharmacol. 2022 Jan;179 (1) :103-124.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

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