Apitolisib

CAT: 0804-HY-13246-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-13246-01Size:5 mg

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Description

Apitolisib (GDC-0980; GNE 390; RG 7422) is a selective, potent, orally bioavailable Class I PI3 kinase and mTOR kinase (TORC1/2) inhibitor with IC50s of 5 nM/27 nM/7 nM/14 nM for PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ, and with a Ki of 17 nM for mTOR.

CAS Number

1032754-93-0

Product Name Alternative

GDC-0980; GNE 390; RG 7422

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; mTOR; PI3K

Type

Reference compound

Related Pathways

Apoptosis; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gdc-0980.html

Concentration

10mM

Purity

99.29

Solubility

DMSO : 14.29 mg/mL (ultrasonic)

Smiles

C[C@@H](C(N1CCN(CC1)CC2=C(C3=NC(C4=CN=C(N=C4)N)=NC(N5CCOCC5)=C3S2)C)=O)O

Molecular Formula

C23H30N8O3S

Molecular Weight

498.60

Precautions

H302, H315, H319, H335

References & Citations

[1]Sutherlin DP, et al. Discovery of a potent, selective, and orally available class I phosphatidylinositol 3-kinase (PI3K) /mammalian target of rapamycin (mTOR) kinase inhibitor (GDC-0980) for the treatment of cancer. J Med Chem, 2011, 54 (21), 7579-7587.|[2]Wallin JJ, et al. GDC-0980 is a novel class I PI3K/mTOR kinase inhibitor with robust activity in cancer models driven by the PI3K pathway. Mol Cancer Ther, 2011, 10 (12), 2426-2436.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Isoform

MTOR; mTORC1; mTORC2; PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ

Alternative Products

Catalog	Name
BUP09690-01	Apitolisib
S2696-5mg	Apitolisib (GDC-0980)
205470	GDC-0980 (Apitolisib)
MBS576253	Apitolisib (GDC-0980, RG7422)
MBS384750-01	GDC-0980 (Apitolisib, RG7422)
A11023-2	GDC-0980 (Apitolisib, RG7422) 2mg
A11023-25	GDC-0980 (Apitolisib, RG7422) 25mg

Apitolisib

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