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Fuscin

CAT: 0804-HY-111321-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-111321-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Fuscin, a fungal metabolite, CCR5 receptor antagonist with anti-HIV effects. Fuscin is a respiration and oxidative phosphorylation inhibitor, and also a mitochondrial SH-dependent transport-linked functions inhibitor[1][2][3].
CAS Number
83-85-2
UNSPSC
12352005
Hazard Statement
H302+H312+H332
Target
Bacterial; CCR; Endogenous Metabolite; HIV; Mitochondrial Metabolism; Oxidative Phosphorylation
Type
Natural Products
Related Pathways
Anti-infection; GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Infection; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/fuscin.html
Solubility
10 mM in DMSO
Smiles
O=C1C=C2C(C(C)O1)=C(O)C(C3=C2CCC(C)(C)O3)=O
Molecular Formula
C15H16O5
Molecular Weight
276.28
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501
References & Citations
[1]K Yoganathan, et al. 10-Methoxydihydrofuscin, fuscinarin, and fuscin, novel antagonists of the human CCR5 receptor from Oidiodendron griseum. J Nat Prod. 2003 Aug;66 (8) :1116-7. |[2]K S Cheah. Fuscin, an inhibitor of respiration and oxidative phosphorylation in ox-neck muscle mitochondria. Biochim Biophys Acta.1972 Jul 12;275 (1) :1-9. |[3]P M Vignais, et al. Fuscin, an inhibitor of mitochondrial SH-dependent transport-linked functions. Biochim Biophys Acta. 1973 Dec 14;325 (3) :357-74.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
CCR5; HIV; Microbial Metabolite

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