Fuscin

CAT: 0931-T37714Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0931-T37714Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

83-85-2

Target

Others, CCR, Endogenous Metabolite, Mitochondrial Metabolism, OXPHOS, HIV Protease, Antibacterial

Related Pathways

Metabolism, GPCR/G Protein, Immunology/Inflammation, Proteases/Proteasome, Microbiology/Virology, Apoptosis, Others

Bioactivity

Fuscin is a quinonoid fungal metabolite originally isolated from O. fuscum that has diverse biological activities. It inhibits binding of the ADP/ATP translocase inhibitor atractyloside to rat liver mitochondria in an ADP-dependent manner when used at a concentration of 50 μM in a radioligand binding assay. Fuscin (20 μM) reduces the glutathione content of rat liver mitochondria to 28% of controls and inhibits NADH oxidation in sonicated pigeon heart mitochondria preparations in a concentration-dependent manner. It competes with macrophage inflammatory protein 1α (MIP-1α) for binding to CCR5 chemokine receptors in vitro with an IC50 value of 21 μM.

Smiles

CC1OC(=O)C=C2C3=C(OC(C)(C)CC3)C(=O)C(O)=C12 |t:5,7,19|

Molecular Formula

C15H16O5

Molecular Weight

276.288

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Catalog	Name
BA1546-1	Fuscin

Fuscin

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