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Insulin efsitora alfa

CAT: 0804-HY-P99665-01Size: 500 µgDry Ice: YesHazardous: No
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CAT#:0804-HY-P99665-01Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Insulin efsitora alfa (LY-3209590) is a selective agonist of insulin receptor (IR) . Insulin efsitora alfa is a fusion protein composed of human IR agonists fused with the crystallizable (Fc) domain of human immunoglobulin G2 (IgG2) fragment, with a molecular weight of 64.1 kDa. Insulin efsitora alfa is well tolerated and has potential applications in diabetes[1].
CAS Number
2131038-11-2
Product Name Alternative
LY-3209590
UNSPSC
12352203
Target
Insulin Receptor
Type
Inhibitory Antibodies
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/insulin-efsitora-alfa.html
Purity
99.80
Solubility
10 mM in DMSO
Smiles
[Insulinefsitoraalfa]
Molecular Weight
(64.1 kDa)
References & Citations
[1]Heise T, et al. Pharmacokinetic and pharmacodynamic properties of the novel basal insulin Fc (insulin efsitora alfa), an insulin fusion protein in development for once-weekly dosing for the treatment of patients with diabetes. Diabetes Obes Metab. 2023 Apr;25 (4) :1080-1090. |[2]Moyers JS, et al. Preclinical Characterization of LY3209590, a Novel Weekly Basal Insulin Fc-Fusion Protein. J Pharmacol Exp Ther. 2022 Sep;382 (3) :346-355.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 2

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