Acacetin

Acacetin

• CAS Number: 480-44-4
• UNSPSC Description: Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an orally active flavonoid derived from Dendranthema morifolium. Acacetin docks in the ATP binding pocket of PI3Kγ. Acacetin causes cell cycle arrest and induces apoptosis and autophagy in cancer cells. Acacetin has potent anti-cancer and anti-inflammatory activity and has the potential for pain-related diseases research[1][2].
• Target Antigen: Apoptosis; Autophagy
• Type: Natural Products
• Related Pathways: Apoptosis;Autophagy
• Applications: Cancer-programmed cell death
• Field of Research: Cancer; Inflammation/Immunology; Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/Acacetin.html
• Purity: 99.83
• Solubility: DMSO : 125 mg/mL (ultrasonic)
• Smiles: O=C1C=C(C2=CC=C(OC)C=C2)OC3=CC(O)=CC(O)=C13
• Molecular Weight: 284.26
• References & Citations: [1]Hong-Wei Zhang, et al. Flavonoids inhibit cell proliferation and induce apoptosis and autophagy through downregulation of PI3Kγ mediated PI3K/AKT/mTOR/p70S6K/ULK signaling pathway in human breast cancer cells. Sci Rep. 2018 Jul 26;8(1):11255.|[2]Sang Keun Ha, et al. Acacetin attenuates neuroinflammation via regulation the response to LPS stimuli in vitro and in vivo. Neurochem Res. 2012 Jul;37(7):1560-7.|[3]A I Carballo-Villalobos, et al. Evidence of mechanism of action of anti-inflammatory/antinociceptive activities of acacetin. Eur J Pain. 2014 Mar;18(3):396-405.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported