Acacetin

CAT: 0804-HY-N0451-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N0451-01Size:5 mg
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Description
Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an orally active flavonoid derived from Dendranthema morifolium. Acacetin docks in the ATP binding pocket of PI3Kγ. Acacetin causes cell cycle arrest and induces apoptosis and autophagy in cancer cells. Acacetin has potent anti-cancer and anti-inflammatory activity and has the potential for pain-related diseases research[1][2].
CAS Number
[480-44-4]
Product Name Alternative
5,7-Dihydroxy-4'-methoxyflavone
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Apoptosis; Autophagy
Type
Natural Products
Related Pathways
Apoptosis; Autophagy
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Acacetin.html
Concentration
10mM
Purity
99.71
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C1C=C(C2=CC=C(OC)C=C2)OC3=CC(O)=CC(O)=C13
Molecular Formula
C16H12O5
Molecular Weight
284.26
Precautions
H315, H319, H335
References & Citations
[1]Hong-Wei Zhang, et al. Flavonoids inhibit cell proliferation and induce apoptosis and autophagy through downregulation of PI3Kγ mediated PI3K/AKT/mTOR/p70S6K/ULK signaling pathway in human breast cancer cells. Sci Rep. 2018 Jul 26;8 (1) :11255.|[2]Sang Keun Ha, et al. Acacetin attenuates neuroinflammation via regulation the response to LPS stimuli in vitro and in vivo. Neurochem Res. 2012 Jul;37 (7) :1560-7.|[3]A I Carballo-Villalobos, et al. Evidence of mechanism of action of anti-inflammatory/antinociceptive activities of acacetin. Eur J Pain. 2014 Mar;18 (3) :396-405.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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