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Leflunomide (Standard)

CAT: 0804-HY-B0083R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0083R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Leflunomide (Standard) is the analytical standard of Leflunomide. This product is intended for research and analytical applications. Leflunomide is a pyrimidine synthesis inhibitor, inhibiting dihydroorotate dehydrogenase (DHODH), and acts as a disease-modifying antirheumatic agent.
CAS Number
75706-12-6
Product Name Alternative
HWA486 (Standard) ; RS-34821 (Standard) ; SU101 (Standard)
UNSPSC
12352005
Hazard Statement
H301-H315-H319-H335
Target
Bacterial; Dihydroorotate Dehydrogenase; Endogenous Metabolite; Reference Standards
Type
Reference Standards
Related Pathways
Anti-infection; Metabolic Enzyme/Protease; Others
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/leflunomide-standard.html
Smiles
O=C(C1=C(C)ON=C1)NC2=CC=C(C(F)(F)F)C=C2
Molecular Formula
C12H9F3N2O2
Molecular Weight
270.21
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Davis JP, et al. The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase. Biochemistry. 1996 Jan 30;35 (4) :1270-3.|[2]Xu X, et al. Inhibition of protein tyrosine phosphorylation in T cells by a novel immunosuppressive agent, leflunomide. J Biol Chem. 1995 May 26;270 (21) :12398-403.|[3]Fox RI, et al. Mechanism of action for leflunomide in rheumatoid arthritis. Clin Immunol. 1999 Dec;93 (3) :198-208.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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