Antipain (dihydrochloride)

Antipain (dihydrochloride)

• CAS Number: 9007-83-4
• UNSPSC Description: Antipain dihydrochloride is a protease inhibitor isolated from Actinomycetes. Antipain dihydrochloride inhibits N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced transformation and increases chromosomal aberrations. Antipain dihydrochloride restricts uterine DNA synthesis and function in mice[1][2][3][4].
• Target Antigen: DNA/RNA Synthesis; Ser/Thr Protease
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
• Field of Research: Cancer; Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/antipain-dihydrochloride.html
• Purity: 95.0
• Solubility: H2O : 50 mg/mL (ultrasonic)
• Smiles: OC([C@@H](NC(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(NC(C([H])=O)CCCNC(N)=N)=O)=O)=O)CC1=CC=CC=C1)=O.[H]Cl.[H]Cl
• Molecular Weight: 677.62
• References & Citations: [1]DiPaolo JA, et al. Antipain inhibits N-methyl-N'-nitro-N-nitrosoguanidine-induced transformation and increases chromosomal aberrations. Proc Natl Acad Sci U S A. 1980 Nov;77(11):6649-53.|[2]Suda H,et al. Antipain, a new protease inhibitor isolated from actinomycetes. J Antibiot (Tokyo). 1972 Apr;25(4):263-6.|[3]Sudha VT, et al. Identification of a serine protease as a major allergen (Per a 10) of Periplaneta americana. Allergy. 2008 Jun;63(6):768-76.|[4]Nomura T, et al. Inhibiting effects of antipain on urethane-induced lung neoplasia in mice. Br J Cancer. 1980;42(4):624‐626.|[5]Katz J, et al. Antipain and leupeptin restrict uterine DNA synthesis and function in mice. Proc Natl Acad Sci U S A. 1977;74(9):3754‐3757.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported