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Histamine (phosphate) (Standard)

CAT: 0804-HY-A0129R-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-A0129R-01Size:25 mg
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Description
Histamine phosphate (Standard) is the analytical standard of Histamine phosphate. This product is intended for research and analytical applications. Histamine phosphate is the agonist for histamine receptor and a vasodilator. Histamine phosphate is an organic nitrogen compound that participates in local immune responses, regulates intestinal physiological functions, and acts as a neurotransmitter. Histamine phosphate affects p38 MAPK/Akt signaling pathway, exhibits antitumor, antioxidant and anti-inflammatory activities. Histamine phosphate can be used in the research of acute myeloid leukemia, malignant melanoma, and renal cell carcinoma[1][2][3][4][5][6][7].
CAS Number
51-74-1
Product Name Alternative
Histamine diphosphate (Standard)
UNSPSC
12352005
Target
Akt; Apoptosis; Endogenous Metabolite; Histamine Receptor; p38 MAPK; Reactive Oxygen Species (ROS) ; Reference Standards
Type
Reference Standards
Related Pathways
Apoptosis; GPCR/G Protein; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; Others; PI3K/Akt/mTOR
Field of Research
Cancer; Endocrinology; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/histamine-phosphate-standard.html
Smiles
NCCC1=CNC=N1.O=P(O)(O)O.O=P(O)(O)O
Molecular Formula
C5H15N3O8P2
Molecular Weight
307.14
References & Citations
[1]Okabe S, et al. Effects of cimetidine, a histamine H2-receptor antagonist, on various experimental gastric and duodenal ulcers. Am J Dig Dis. 1977 Aug;22 (8) :677-84. |[2]Rietveld S et al. The influence of respiratory sounds on breathlessness in children with asthma: a symptom-perceptionapproach. Health Psychol. 1997 Nov;16 (6) :547-53. |[3]Malmberg-Aiello P, et al., Role of histamine in rodent antinociception. Br J Pharmacol. 1994 Apr;111 (4) :1269-79. |[4]Medina V, et al., Histamine-mediated signaling processes in human malignant mammary cells. Cancer Biol Ther. 2006 Nov;5 (11) :1462-71.|[5]Ferreira R, et al., Histamine modulates microglia function. J Neuroinflammation. 2012 May 8;9:90. |[6]MARTIN L. The effects of histamine on the vaginal epithelium of the mouse. J Endocrinol. 1962 Jan;23:329-40. |[7]Yang LP, et al. Spotlight on histamine dihydrochloride in acute myeloid leukaemia. Drugs Aging. 2011 Apr 1;28 (4) :325-9.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

Chemical Information

Histamine Phosphate

Histamine phosphate is a phosphate salt that is the diphosphate salt of histamine. It has a role as a histamine agonist. It contains a histamine.

CAS Number51-74-1
PubChem CID65513
IUPAC Name2-(1H-imidazol-5-yl)ethanamine;phosphoric acid
Molecular FormulaC5H15N3O8P2
Molecular Weight307.14
Topological Polar Surface Area210
Hydrogen Bond Donor Count8
Hydrogen Bond Acceptor Count10
Rotatable Bond Count2
Heavy Atom Count18
Formal Charge0
Complexity114
SMILES
C1=C(NC=N1)CCN.OP(=O)(O)O.OP(=O)(O)O
InChI
InChI=1S/C5H9N3.2H3O4P/c6-2-1-5-3-7-4-8-5;2*1-5(2,3)4/h3-4H,1-2,6H2,(H,7,8);2*(H3,1,2,3,4)
InChIKey
ZHIBQGJKHVBLJJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Histamine Phosphate
CAS: 51-74-1
CID: 65513
Formula: C5H15N3O8P2
MW: 307.14
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight307.14
Hydrogen Bond Donor Count8
Hydrogen Bond Acceptor Count10
Rotatable Bond Count2
Exact Mass307.03343844
Monoisotopic Mass307.03343844
Topological Polar Surface Area210 Ų
Heavy Atom Count18
Formal Charge0
Complexity114
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count3
Compound Is CanonicalizedYes

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