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UBE3A (N) Antibody, Rabbit Polyclonal

CAT: 0013-GTR18212091Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0013-GTR18212091Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Rabbit polyclonal to UBE3A. Ubiquitin-protein ligase E3A (UBE3A) is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B. UBE3A catalyzes the high-risk human papilloma virus E6-mediated ubiquitination of p53/TP53, contributing to the neoplastic progression of cells infected by these viruses. Additionally, UBE3A may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. Finally, UBE3A also promotes its own degradation in vivo.
Product Name Alternative
Anti Ubiquitin-protein ligase E3A antibody, anti E6AP ubiquitin-protein ligase antibody, anti Human papillomavirus E6-associated protein antibody, anti Oncogenic protein-associated protein E6-AP antibody, anti Renal carcinoma antigen NY-REN-54 antibody, anti E6AP antibody, anti EPVE6AP antibody, anti HPVE6A antibody
UniProt
Q05086
Reactivity
Human
Immunogen
N-terminal region of human UBE3A
Clonality
Polyclonal
Conjugation
Unconjugated
Field of Research
Epigenetics, Infectious Diseases, Neuroscience
Concentration
100 μg/ml BSA
Dilution
WB:1:1000-1:3000
Purity
Affinity purification
Molecular Weight
101
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
WB: The apparent protein size on WB may be different from the calculated M.W. due to modifications.Experiment Notes: Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the N-terminal region of human UBE3A. Antibodies were purified by affinity purification using immunogen.
Tested Applications
WB
Host or Source
Rabbit
Preservative
0.01% NaN3

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