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SNX13 rabbit pAb

CAT: 0855-ES13032-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES13032-01Size:50 µL
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Background
This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha (s), accelerates its GTP hydrolysis, and attenuates G alpha (s) -mediated signaling. Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking. [provided by RefSeq, Jul 2008]
Description
This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha (s), accelerates its GTP hydrolysis, and attenuates G alpha (s)-mediated signaling. Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking. [provided by RefSeq, Jul 2008],
Product Name Alternative
Sorting nexin-13 (RGS domain- and PHOX domain-containing protein) (RGS-PX1)
UniProt
Q9Y5W8
Swiss Prot
Q9Y5W8
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human SNX13 AA range: 602-652
Target
SNX13
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Buffer
-20°C/1 year
Molecular Weight
105kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
105kD
Fragment
IgG
Subcellular Location
Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side .
Other Product Names
Sorting nexin-13 (RGS domain- and PHOX domain-containing protein) (RGS-PX1)
Gene ID (Human)
23161

UniProtKB · Q9Y5W8

Sorting nexin-13

SNX13_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9Y5W8
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SNX13
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B2RCI9, O94821, Q8WVZ2, Q8WXH8
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

EndosomeMembrane

Ligand

Lipid-binding

Biological process

Protein transportTransport

Molecular function

Signal transduction inhibitor

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