SNX13 rabbit pAb

• Background:

  This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha (s), accelerates its GTP hydrolysis, and attenuates G alpha (s) -mediated signaling. Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking. [provided by RefSeq, Jul 2008]

• Description:

  This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha (s), accelerates its GTP hydrolysis, and attenuates G alpha (s)-mediated signaling. Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking. [provided by RefSeq, Jul 2008],

• Synonyms:

  Sorting nexin-13 (RGS domain- and PHOX domain-containing protein) (RGS-PX1)

• Gene ID:

  23161

• UniProt:

  Q9Y5W8

• Cellular Locus:

  Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side.

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse

• Reactivity:

  Human; Mouse

• Immunogen:

  Synthesized peptide derived from human SNX13 AA range: 602-652

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Source:

  Rabbit

• Applications:

  WB

• Validated Applications:

  WB

• Stability:

  -20°C/1 year

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:500-2000

• Molecular Weight:

  105kD

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

• Observed Molecular Weight:

  105 kD

• Subcellular Location:

  Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side .

• Other Product Names:

  Sorting nexin-13 (RGS domain- and PHOX domain-containing protein) (RGS-PX1)

• Gene ID (Human):

  23161

• SwissProt (Human):

  Q9Y5W8