NMB-1

• UNSPSC Description:

  NMB-1 is a conopeptide analogue. NMB-1 selectively inhibits sustained mechanically activated currents in sensory neurons (IC50: 1 μM). NMB-1 inhibits mechanical pain. NMB-1 can be used for research of hearing and pressure-evoked pain[1][2].

• Target Antigen:

  Others

• Type:

  Peptides

• Related Pathways:

  Others

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/nmb-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C([C@@H](N)CC1=CC=CC=C1)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N2[C@H]3CCC2)=O)[C@H](CC)C)=O)CC(C)C)=O)CSSC[C@H](NC3=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]4CC5=CC=CC=C5)=O)CC6=CC=CC=C6)=O)CCCCN)=O)CCCCN)=O)CC7=CNC=N7)=O)CC(N)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)=O)CSSC[C@H](NC4=O)C(N)=O)=O)CCCNC(N)=N)=O)CC8=CNC9=CC=CC=C89)=O)CC(N)=O

• Molecular Weight:

  2466.98

• References & Citations:

  [1]Drew LJ, et al. High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain. PLoS One. 2007 Jun 13;2(6):e515.|[2]Raouf R, et al. Inhibition of somatosensory mechanotransduction by annexin A6. Sci Signal. 2018 Jun 19;11(535):eaao2060.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2843557-76-4