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Nipecotic acid

CAT: 0804-HY-69359-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0804-HY-69359-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nipecotic acid ((±) -β-Homoproline) is a potent inhibitor of neuronal and glial-aminobutyric acid (GABA) uptake in vitro. Nipecotic acid can also directly activate GABAA-like chloride channels, with an EC50 of approximately 300 μM[1][2].
CAS Number
498-95-3
Product Name Alternative
(±) -β-Homoproline; Hexahydronicotinic acid; 3-Carboxypiperidine
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nipecotic-acid.html
Purity
98.0
Solubility
DMSO : < 1 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)
Smiles
O=C(C1CNCCC1)O
Molecular Formula
C6H11NO2
Molecular Weight
129.16
Precautions
H315, H319, H335
References & Citations
[1]Barrett-Jolley R, et, al. Nipecotic acid directly activates GABA (A) -like ion channels. Br J Pharmacol. 2001 Jul;133 (5) :673-8.|[2]Dhanawat M, et, al. Design, Synthesis and Enhanced BBB Penetration Studies of L-serine-Tethered Nipecotic Acid-Prodrug. Drug Res (Stuttg) . 2021 Feb;71 (2) :94-103.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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