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PAK2 (N2) Antibody, Rabbit Polyclonal

CAT: 0013-GTR18210333Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0013-GTR18210333Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Rabbit polyclonal to PAK2.p21-activated kinase 2 (PAK2) belongs to the protein kinase superfamily, STE Ser/Thr protein kinasefamily and STE20 subfamily. PAK2 plays a role in a variety of different signaling pathways includingcytoskeleton regulation, cell motility, cell cycle progression, apoptosis and proliferation. PAK2 acts asdownstream effector of the small GTPases CDC42 and RAC1. Activation of PAK2 by the binding ofactive CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylationof PAK2. Activated PAK2 can phosphorylate many substrates including histone H4, BAD, ribosomalprotein S6 and MBP. Additionally, PAK2 associates with ARHGEF7 to perform kinaseindependentfunctions such as spindle orientation control during mitosis. On the other hand, apoptoticstimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34 thattranslocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway.
Product Name Alternative
Anti-PAK2 antibody, anti-Serine antibody, anti-threonineprotein kinase PAK 2 antibody, anti-GammaPAK antibody, anti-PAK65 antibody, anti-S6 antibody, anti-H4 kinase antibody, anti-p21activated kinase 2 antibody, anti- PAK2 antibody, anti-p58 antibody
UniProt
Q13177
Reactivity
Human, Mouse
Immunogen
N-terminal region of human PAK2
Clonality
Polyclonal
Conjugation
Unconjugated
Field of Research
Cell Biology
Dilution
WB:1:500-1:2000
Purity
Affinity purification
Molecular Weight
58
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
WB
Host or Source
Rabbit
Preservative
0.01% NaN3

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