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TET1 (C2) Antibody, Rabbit Polyclonal

CAT: 0013-GTR18210298Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0013-GTR18210298Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Rabbit polyclonal to TET1.TET1 is a methylcytosine dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) . Methylation at the C5 position ofcytosine bases is an epigenetic modification of the mammalian genome which plays an important rolein transcriptional regulation. TET1 might initiate a process leading to cytosine demethylation throughdeamination into 5-hydroxymethyluracil (5hmU) and subsequent replacement by unmethylatedcytosine by the base excision repair system. TET1 preferentially binds to CpG-rich sequences atpromoters of both transcriptionally active and polycomb-repressed genes. By controlling the levels of5mC and 5hmC at gene promoters, it may regulate the gene silencing induced by cytosinemethylation. It has been shown that TET1 plays an important role in embryonic stem cellsmaintenance and regulating the balance between pluripotency and lineage commient.
Product Name Alternative
Anti-TET1 antibody, anti-Methylcytosine dioxygenase TET1 antibody, anti-CXXCtype zinc finger protein 6 antibody, anti-Leukemiaassociated protein with a CXXC domain antibody, anti-Teneleven translocation 1 gene protein antibody, anti-CXXC6 antibody, anti-KIAA1676 antibody, anti-LCX antibody
UniProt
Q8NFU7
Reactivity
Human, Mouse
Immunogen
C-terminal region of human TET1
Clonality
Polyclonal
Conjugation
Unconjugated
Field of Research
Metabolism Research
Dilution
WB:1:500-1:1000, ChIP: 1:100- 1:200
Purity
Affinity purification
Molecular Weight
235
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
ChIP, WB
Host or Source
Rabbit
Preservative
0.01% NaN3

UniProtKB · Q8NFU7

Methylcytosine dioxygenase TET1

TET1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8NFU7
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TET1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
1.14.11.80
Processing
—
Secondary accessions
A0A023HHK9, A0A023HHL0, Q5VUP7, Q7Z6B6, Q8TCR1, Q9C0I7
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorChromatin regulatorDevelopmental proteinDioxygenaseDNA-bindingOxidoreductaseRepressor

Coding sequence diversity

Alternative promoter usageAlternative splicingChromosomal rearrangement

Cellular component

ChromosomeNucleus

PTM

GlycoproteinIsopeptide bondPhosphoproteinUbl conjugation

Ligand

IronMetal-bindingZinc

Biological process

TranscriptionTranscription regulation

Domain

Zinc-finger

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