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IDH2 (N) Antibody, Rabbit Polyclonal

CAT: 0013-GTR18210263Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0013-GTR18210263Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Rabbit polyclonal to IDH2.Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate.These enzymes belong to two distinct subclasses, one utilizes NAD (+) as the electron acceptor andthe other NADP (+) . Five isocitrate dehydrogenases have been reported: three NAD (+) -dependentwhich localize to the mitochondrial matrix; and two NADP (+) -dependent, one of which is mitochondrialand the other predominantly cytosolic. Each NADP (+) -dependent isozyme is a homodimer. IDH2 isthe NADP (+) -dependent isocitrate dehydrogenase found in the mitochondria, which plays a role inintermediary metabolism and energy production. IDH2 may tightly associate or interact with thepyruvate dehydrogenase complex. Defects in IDH2 are the cause of D-2-hydroxyglutaric aciduria type2 (D2HGA2), a neurometabolic disorder causing developmental delay, epilepsy, hypotonia, anddysmorphic features.
Product Name Alternative
Anti-IDH2 antibody, anti-Isocitrate dehydrogenase [NADP] mitochondrial antibody, anti-IDH antibody, anti-ICDM antibody, anti-IDP antibody, anti-NADP (+) specific ICDH antibody, anti- Oxalosuccinate decarboxylase antibody
UniProt
P48735
Reactivity
Human, Mouse
Immunogen
N-terminal region of human IDH2
Clonality
Polyclonal
Conjugation
Unconjugated
Field of Research
Metabolism Research
Dilution
WB:1:1000-1:5000
Purity
Affinity purification
Molecular Weight
51
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
WB
Host or Source
Rabbit
Preservative
0.01% NaN3

UniProtKB · P48735

Isocitrate dehydrogenase [NADP], mitochondrial

IDHP_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P48735
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IDH2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
IDH
EC number
1.1.1.42
Processing
Precursor
Secondary accessions
B2R6L6, B4DFL2, Q96GT3
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

Acetylation

Coding sequence diversity

Alternative splicing

Disease

Disease variant

Biological process

Glyoxylate bypassTricarboxylic acid cycle

Ligand

MagnesiumManganeseMetal-bindingNADP

Cellular component

Mitochondrion

Molecular function

Oxidoreductase

Domain

Transit peptide

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