Products for Research Use Only

TSC2 (C2) Antibody, Rabbit Polyclonal

CAT: 0013-GTR18210209Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0013-GTR18210209Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Rabbit polyclonal to TSC2.Tuberin (TSC2) forms a complex with TSC1 and inhibits the nutrient-mediated or growth factorstimulatedphosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling.TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of theprotein kinase activity of mTORC1. It is implicated as a tumor suppressor. TSC2 is involved inmicrotubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling.Mutations in TSC2 lead to constitutive activation of RAP1A in tumors. Defects in TSC2 causetuberous sclerosis type 2 (TSC2) and lymphangioleiomyomatosis (LAM) .
Product Name Alternative
Anti-TSC2 antibody, anti-Tuberin antibody, anti-Tuberous sclerosis 2 protein antibody, anti-TSC4 antibody
UniProt
P49815
Reactivity
Human, Mouse
Immunogen
C-terminal region of human TSC2
Clonality
Polyclonal
Conjugation
Unconjugated
Field of Research
Signal Transduction
Dilution
WB:1:500-1:1000
Purity
Affinity purification
Molecular Weight
201
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
WB
Host or Source
Rabbit
Preservative
0.01% NaN3