IKZF1 (M) Antibody, Rabbit Polyclonal

Rabbit polyclonal to IKZF1.Ikaros family zinc finger protein 1 (IKZF1) is a transcription factor that belongs to the family of zincfingerDNA binding proteins associated with chromatin remodeling. The expression of IKZF1 isrestricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator oflymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoformshave been described for this gene. All isoforms share a common C-terminal domain, which containstwo zinc finger motifs required for hetero-or homodimerization and for interactions with other proteins.The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and thenuclear localization signal, resulting in members with and without DNA-binding properties. Only a fewisoforms display high affinity binding to a specific core DNA sequence element in the promoters oftarget genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and thought tofunction as dominant negative factors. Overexpression of some dominant-negative isoforms havebeen associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL) .

Anti-IKZF1 antibody, anti-DNAbinding protein Ikaros antibody, anti-Ikaros family zinc finger protein 1 antibody, anti-Lymphoid transcription factor LyF1 antibody, anti- IK1 antibody, anti-IKAROS antibody, anti-LYF1 antibody, anti-ZNFN1A1 antibody

Q13422

Human

Middle region of human IKZF1

Unconjugated

Epigenetics & Chromatin

WB:1:1000-1:5000

Affinity purification

58

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

For research use only.

WB

Rabbit