Products for Research Use Only

SHC1 (C2) Antibody, Rabbit Polyclonal

CAT: 0013-GTR18210154Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0013-GTR18210154Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Rabbit polyclonal to SHC1.SHC-transforming protein 1 (SHC1) is a signaling adapter that couples activated growth factorreceptors to signaling pathways, such as the signaling cascade initiated by activated KIT andKITLG/SCF. The SHC1 gene encodes three main isoforms that differ in activities and subcellularlocations, including p46Shc, p52Shc and p66Shc. Isoforms p46Shc and p52Shc, oncephosphorylated, couple activated receptor tyrosine kinases to Ras via the recruient of theGRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoformp66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulatethe cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target ofthe tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induceelevation of intracellular oxidants, cytochrome c release and apoptosis.
Product Name Alternative
Anti-SHC1 antibody, anti-SHCtransforming protein 1 antibody, anti-SHCtransforming protein 3 antibody, anti-SHCtransforming protein A antibody, anti-Src homology 2 domaincontainingtransforming protein C1 antibody, anti-SH2 domain protein C1 antibody, anti-SHC antibody, anti-SHCA antibody
UniProt
P29353
Reactivity
Human
Immunogen
C-terminal region of human SHC1
Clonality
Polyclonal
Conjugation
Unconjugated
Field of Research
Cardiovascular Research
Dilution
WB:1:1000-1:5000
Purity
Affinity purification
Molecular Weight
63
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
WB
Host or Source
Rabbit
Preservative
0.01% NaN3