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KDM1A (M) Antibody, Rabbit Polyclonal

CAT: 0013-GTR18210054Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0013-GTR18210054Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Rabbit polyclonal to KDM1A.Lysine-specific histone demethylase 1A (KDM1A) is a histone demethylase that demethylates both'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or acorepressor, depending on the context. KDM1A acts as a corepressor by mediating demethylation ofH3K4me, a specific tag for epigenetic transcriptional activation. KDM1A can demethylate both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me, and may play a role in the repression of neuronalgenes. KDM1A also acts as a coactivator of androgen receptor (ANDR) -dependent transcription, bybeing recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag forepigenetic transcriptional repression. KDM1A is required for gastrulation during embryogenesis.
Product Name Alternative
Anti-KDM1A antibody, anti-Lysinespecific histone demethylase 1A antibody, anti-BRAF35HDAC complex protein BHC110 antibody, anti-Flavincontaining amine oxidase domaincontaining protein 2 antibody, anti-AOF2 antibody, anti-KDM1 antibody, anti-KIAA0601 antibody, anti-LSD1 antibody
UniProt
O60341
Reactivity
Human, Mouse
Immunogen
Middle region of human KDM1A
Clonality
Polyclonal
Conjugation
Unconjugated
Field of Research
Metabolism Research
Dilution
WB:1:1000-1:5000
Purity
Affinity purification
Molecular Weight
93
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
WB
Host or Source
Rabbit
Preservative
0.01% NaN3

UniProtKB · O60341

Lysine-specific histone demethylase 1A

KDM1A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O60341
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
KDM1A
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
1.14.11.-, 1.14.11.65, 1.14.99.66
Processing
—
Secondary accessions
A8MWP9, Q5TH94, Q5TH95, Q86VT7, Q8IXK4, Q8NDP6, Q8TAZ3, Q96AW4
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Molecular function

Chromatin regulatorDevelopmental proteinOxidoreductaseRepressor

Cellular component

ChromosomeNucleus

Domain

Coiled coil

Disease

Cushing syndromeDisease variant

Ligand

FADFlavoprotein

Biological process

TranscriptionTranscription regulation

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