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AGER (N) Antibody, Rabbit Polyclonal

CAT: 0013-GTR18209954Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0013-GTR18209954Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Rabbit polyclonal to AGER.Advanced glycosylation end product-specific receptor (AGER) is also known as receptor for advancedglycation end products AGE), a member of the immunoglobulin superfamily of cell surfacemolecules. AGER is expressed as full-length, membrane-bound RAGE isoform 1 or as a secretedprotein that lacks a transmembrane domain. The observed M.W. of AGER is 48-58 kD. It is a receptorfor a number of different molecules including the ambloidogenic form of serum amyloid A, amyloidbetaprotein, members of the S100/calgranulin superfamily and advanced glycation end products. Itacts as mediator of both acute and chronic vascular inflammation in conditions such asatherosclerosis and in particular as a complication of diabetes. Alternative splicing yields twotranscript variants encoding different isoforms.
Product Name Alternative
Anti-AGER antibody, anti-AGER antibody, anti-RAGE antibody, anti-Receptor for advanced glycosylation end products antibody, anti-DAMA358M23.4 antibody, anti-MGC22357 antibody
UniProt
Q15109
Reactivity
Human, Mouse
Immunogen
N-terminal region of human AGER
Clonality
Polyclonal
Conjugation
Unconjugated
Field of Research
Epigenetics & Chromatin
Dilution
WB:1:1000-1:5000
Purity
Affinity purification
Molecular Weight
43
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
WB
Host or Source
Rabbit
Preservative
0.01% NaN3

UniProtKB · Q15109

Advanced glycation end product-specific receptor

RAGE_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q15109
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
AGER
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A2BFI7, A6NKF0, A7Y2U9, B0V176, Q15279, Q3L1R4, Q3L1R5, Q3L1R6, Q3L1R7, Q3L1R8, Q3L1S0, Q86SN1, Q9H2X7, Q9Y3R3, V5R6A3
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneCell projectionEndosomeMembraneNucleusSecreted

PTM

Disulfide bondGlycoproteinPhosphoproteinUbl conjugation

Biological process

DNA damageDNA repairDNA replicationInflammatory responsePhagocytosis

Molecular function

DNA-bindingReceptorRNA-binding

Domain

Immunoglobulin domainRepeatSignalTransmembraneTransmembrane helix

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